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Portfolio Companies

GCIC supported companies are developing innovative solutions to treat cardiovascular diseases and conditions and contributing to the economic development of Ohio.

Akebia Therapeutics

Learn more about Akebia Therapeutics

Akebia is a Cincinnati, Ohio based company that focuses on clinical development of novel compounds for anemia and ischemia-related disorders, with a focus on peripheral artery disease. Two preclinical programs are in late phase discovery stages with all drug candidates targeted to enter clinical stages within three years.

Arteriocyte

Learn more about Arteriocyte

Arteriocyte is a Cleveland, Ohio and Hopkinton, Massachusetts based company that develops cellular therapies and is currently pursuing cell-based therapeutics and tissue engineering products for the treatment of ischemia and other disease conditions.

Athersys

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Athersys is a Cleveland, Ohio based company developing a growing pipeline of therapeutics designed to treat cardiovascular disease and other conditions. Athersys is currently developing pharmaceutical-like cell therapies, based upon its proprietary multipotent adult progenitor cell technology, for the treatment of congestive heart failure, acute myocardial infarction and other cardiovascular conditions.

AtriCure

Learn more about Atricure

AtriCure is headquartered near Cincinnati, Ohio and has assembled experts in the medical device industry to form a highly effective team dedicated to serving patients, medical professionals, and investors. Using their proprietary bipolar ablation technology, AtriCure has developed a family of products which are used in conjunction with elective surgical ablation procedures. Building on this technical platform, they have developed products which enable physicians to treat patients through minimally invasive procedures in the operating room.

Blue Ash Therapeutics

Learn more about Blue Ash Therapeutics

Blue Ash Therapeutics, is a Cincinnati-based company founded to develop and commercialize acute-care cardiovascular drugs. The initial focus is the late-stage antiarrhythmic drug Azimilide as an adjunctive therapy in patients with implantable cardioverter-defibrillators (ICDs).

CardioCeption

Learn more about CardioCeption

CardioCeption LLC, was formed in 2009 in Cincinnati, Ohio. The company is developing non-traumatic means of eliciting remote cardioprotection during MI, based upon novel discoveries by laboratories at the University of Cincinnati College of Medicine. CardioCeption is currently running translational trials in a large animal model to optimize this therapy. Based upon these results and ongonig clinical trials, the company will pursue R&D to expand the indications and commercialize the application of the technology. 

CardioInsight

Learn more about CardioInsight

CardioInsight is a Cleveland Ohio based company developing electrocardiographic imaging which noninvasively maps electrical activity on the surface of the heart. CardioInsight’s commercialization grant will be used toward software development for its first commercial product.

CardioStar

Learn more about CardioStar

CardioStar is a Mentor, Ohio based company developing non-invasive sensor technologies for continuous patient monitoring of cardiac and vascular parameters.

Cell Targeting, Inc.

Learn more about Cell Targeting, Inc.

Cell Targeting, Inc. is a preclinical-stage company developing a drug delivery platform utilizing a tissue-specific peptide targeting technology with broad therapeutic potential, including delivery of cardiovascular cellular therapies. In January 2011 the company technology was acquired by BioTime, Inc.

ClearFlow, Inc.

Learn more about ClearFlow, Inc.

ClearFlow, Inc. is an Anaheim, CA based company which makes the PleuraFlow® Active Clearance Technology™ System, a new standard of care for post operative cardiac surgery wound drainage.

Cleveland Heart

Learn more about Cleveland Heart

Cleveland Heart is developing a Left Ventricular Assist System intended to provide long-term mechanical circulatory support for patients with terminal heart failure who are unresponsive to conventional therapies.

Cleveland HeartLab, LLC

Learn more about Cleveland HeartLab, LLC

Cleveland HeartLab, LLC is a Cleveland-based specialty clinical laboratory and disease management company focused on novel molecular biomarker technologies and the creation of proprietary diagnostic tests. The company has developed a profile of tests focused on managing and reducing inflammation, a root cause of heart disease.

Cryothermic Systems

Learn more about Cryothermic Systems

Cryothermic Systems, founded in Cleveland, Ohio in 2008, is a medical device company that has developed a series of products that cool the brain during cardiac arrest, stroke or traumatic brain injury. The Excel Cryo® Cooling System is an easy to use, non-invasive 10 second solution for first responders to induce cerebral cooling. The unique design of the system provides consistent cooling of the brain from incident through to the I.C.U. Therapeutic hypothermia is known to protect the quality of life of patients who might otherwise suffer neurologic damage.

Enable Injections

Learn more about Enable Injections

Enable Injections is a start-up company that has developed a disposable body-worn bolus injector to deliver high viscosity/volume payloads up to 20cc. The system uses a standard vial container closure and can automatically mix lyophilized solutions. Founded March 2010, the company has R&D, operations and manufacturing facilities in Franklin, Ohio.

EXCMR

Learn more about EXCMR

EXCMR is a Columbus, Ohio based company that develops and manufactures medical devices to enhance cardiovascular magnetic resonance imaging. Their innovative MRI-compatible treadmill enables cardiovascular exercise stress testing with MRI.

genae Americas Inc.

Learn more about genae Americas Inc.

genae is an innovative services provider for the medical industries. The development and marketing of medical devices and therapies in today’s global marketplace is a highly regulated process with strict requirements from many competent authorities. genae is a catalyst between the health care authorities, investigators in clinical practice and the medical industry to set up and support development processes. We communicate with civil servants in ministries of health, regional and local healthcare authorities, healthcare associations, healthcare technology assessment bodies, health insurance funds and other relevant parties. genae’s ultimate objective is to support the medical industry in obtaining product approval and in achieving a marketable product and market acceptance, in a timely and cost-effective way, while meeting or exceeding all relevant quality standards.

Ischemia Care

Learn more about Ischemia Care

Ischemia Care is a clinical stage capital efficient, diagnostic laboratory commercializing a blood test called ISCDX for cause of stroke and TIA, including atrial fibrillation. Ischemia Care is currently enrolling in a clinical trial (NCT0214896) designed to lead to commercial adoption of ISCDX through company owned CLIA lab.

Juventas Therapeutics

Learn more about Juventas Therapeutics

Juventas Therapeutics is a private clinical-stage company developing first-in-class cardiovascular biopharmaceuticals that target natural repair pathways. The company’s lead product encodes stromal cell-derived factor-1 (SDF-1) which has been shown to significantly increase end-organ function following tissue injury.

Minimally Invasive Devices, Inc.

Learn more about Minimally Invasive Devices, Inc.

Minimally Invasive Devices, Inc. is a Columbus, OH medical device companies that designs, commercializes, and manufacturers instruments that improve visual clarity during laparoscopic surgery. The company’s flagship product, FloShield, is the first device ever that prevents the lens of the laparoscope from becoming covered with debris, allowing surgeons to operate with a better view and far less interruptions.

Navis Medical

Learn more about Navis Medical

Nervive

Learn more about Nervive Inc.

Nervive Inc. is developing the VitalFlow stimulator, a noninvasive emergency treatment for ischemic stroke. The VitalFlow stimulator is entering clinical testing initially as a hospital-based device; a second version of the VitalFlow stimulator will be miniaturized for use in the ambulance. Nervive is based in Akron, Ohio, and Leipzig, Germany.

NI Medical

Learn more about NI Medical

NI Medical has developed the NICaS, a diagnostic device that can be used with a laptop computer as an impedance-based cardiac monitor. FDA-approved for cardiac diagnosis, the NICaS is a portable device for non-invasively monitoring hemodynamics and can be used for the assessment of certain asymptomatic and unrecognized cardiac conditions.

Perfusion Solutions Inc.

Learn more about Perfusion Solutions Inc.

Perfusion Solutions Inc. is a Cleveland-based company developing an ultra-small circulatory assist platform for left ventricular, right ventricular, adult and pediatric applications.

PeriTec

Learn more about PeriTec Biosciences Ltd.

Peritec Biosciences Ltd. is a Cleveland, Ohio based company aiming to develop vascular and cardiovascular surgical products. The company’s technology is based on the novel combination of self expanding nitinol stent and biological tissue, peritoneum.

Proxy Biomedical Ltd.

Learn more about Proxy Biomedical Ltd.

Proxy Biomedical Ltd., an Irish medical technology company, provides solutions for the medical device sector in the area of biomaterials-focused medical implant design, development and contract manufacturing. With a proven track record in innovative design and quality-assured manufacturing, Proxy Biomedical provides a complete solution to world leading tier-one medical device companies who seek a trusted partner to help realise their product development needs. Proxy Biomedical’s deep understanding of inherent biomaterial properties combined with the use of advanced conversion processes, yield novel platform technologies to address unmet needs in General Surgery, Orthopaedics, Wound Care and Cardiovascular sectors. Their proprietary surgical mesh products are CE marked for distribution within the European Community and FDA approved for distribution within the United States.

Quality Electrodynamics

Learn more about Quality Electrodynamics

Quality Electrodynamics (QED) is a global developer, manufacturer and supplier of advanced medical equipment electronics. Current products include cutting edge MRI radiofrequency (RF) antennas/coils for diagnostic imaging at the full range of magnetic field strengths. Most of these are FDA Class II noninvasive devices used for obtaining diagnostic images for various human anatomies.

Regulatory & Quality Solutions

Learn more about Regulatory & Quality Solutions

R&Q is a team of regulatory and quality experts that provide companies with the best practices it needs to succeed. Our experts are experienced, knowledgeable, and scalable to whatever challenges medical device businesses faces during its entire life cycle. R&Q has been built from the ground up to provide the solutions you need, when you need them, and where they provide optimum value. From strategic advice and guidance, to full spectrum, hands-on regulatory and quality engineering support, R&Q has the resources to ensure the success of any business.

Securus Medical Group

Learn more about Securus Medical Group

Securus Medical Group is developing clinical tools to monitor core body temperature within body cavities. Thermal injury to the tissue due to energy from various sources can create damage to surrounding tissue. Securus will provide clinicians a simple to use, real-time, noncontact, thermal map of body cavity tissue temperature. This information will guide the physician to achieve the desired clinical outcome without risk of injury to surrounding tissue. For more information, please contact Steve Girouard at Sgirouard@securusmg.com.

Sensible Medical Innovations

Learn more about Sensible Medical Innovations

Sensible Medical Innovations has developed a breakthrough modality that is optimal for continuous and wearable use at both home and hospital. Sensible Medical is the industry leader in RF monitoring and imaging. Based on its proprietary ReDS technology the company is addressing a wide range of applications, with current focus on the first effective non-invasive device for congestive heart failure (“CHF”) monitoring.

TheraVasc Inc.

Learn more about TheraVasc Inc.

Founded in 2009, TheraVasc Inc. is a privately held Cleveland, OH corporation (Delaware registered), which is developing an oral formulation of sodium nitrite, TV1001, targeting patient populations with poor blood flow to the extremities, such as patients with peripheral artery disease (PAD), diabetes or peripheral neuropathy. TheraVasc has recently completed a double blind, placebo controlled, Phase IIa clinical trial, which demonstrated the safety of chronic oral administration of its product, evidence of bioactivity and an indication of clinical benefit to patients with PAD, with patients receiving TV1001 reporting a statistically significant reduction in pain. In a collaborative study at the University of Colorado, TV1001 was also shown to be beneficial to otherwise healthy aged individuals, improving vascular function, balance, grip strength and even cognition. Additionally, in a separate trial conducted at the NIH with a topical formulation of sodium nitrite, sickle cell patients with foot ulcers also reported a reduction in pain. Based on these results, TheraVasc is undertaking a study to assess the effects of its second generation oral formulation, TV1001sr, on patients with peripheral neuropathy.

TRIM-edicine, Inc.

Learn more about TRIM-edicine, Inc.

TRIM-edicine, Inc. is a Columbus-based company founded to develop and commercialize protein therapeutics for regenerative medicine. The initial focus is on the use of recombinant MG53 protein in the treatment of ischemia reperfusion injury in a number of different tissues related to cardiovascular disease.

VasoStar

Learn more about VasoStar

VasoStar is a Mentor, Ohio based company developing and commercializing an electromagnetically driven guidewire system that safely improves the success rate for crossing chronic total occlusions in vasculature.

VentureMed Group™

Learn more about VentureMed Group™

VentureMed Group™ (VMG) designs, develops and markets innovative and cost-effective medical devices for treating peripheral artery disease. VMG’s flagship product, the FLEX Scoring Catheter™ is an innovative and cost-effective plaque modification and vessel preparation catheter for scoring any length segment of the superficial-femoral artery (SFA), prior to balloon angioplasty or stent placement, and for emerging opportunities in drug coated balloon and drug eluting stent therapies. FLEX™ is the first and only one-size-fits-all alternative to cutting or scoring balloons and atherectomy devices.

ZIN Medical

Learn more about ZIN

ZIN is a Cleveland, Ohio based company focused on the development of a remote, wireless patient monitoring system based on technology developed with support from NASA. ZIN seeks to commercialize their vMetrics System, a small, configurable device that records and transmits data from a wide variety of biomedical sensors.